Glycogen stores how long to deplete




















Starting a low-carb diet will result in initial weight loss. This happens because when glycogen is stored in your muscle, its bound to water. However, the quick depletion of glycogen and rapid water weight loss will eventually cause weight to return. Keep in mind that these weight fluctuations are water, not fat.

Eating very low-carb is not ideal for high-intensity exercise because the anaerobic system relies on breaking down glucose for energy. Since diets like the ketogenic diet burn fat instead of glucose for fuel, that quick glucose-based energy is not available. During high-intensity exercise, the body shifts to use glycogen as fuel regardless of your carb intake.

That means, if you consume fewer carbs, your body will have less energy to work with therefore compromising your training. Find out more about the ketogenic diet and see if it's really worth all the the hype. That was a lot of science-backed information. Here it is in short:. Glycogen depletion happens when we run out of glycogen stores because of lack of food or intense exercise. When following a low-carb diet, your body needs time to adjust to a new fuel source. For recipes with healthy sources of glucose, sign up for 8fit!

In fact, glucosephosphate allosterically activates glycogen synthase, stimulating the addition of glucose molecules to the glycogen particle. The activity of the glycogen synthase enzyme is controlled by a cascade of events that rely on phosphorylation and dephosphorylation reactions that decrease and increase the activity of the enzyme in concert with similar phosphorylation-dephosphorylation reactions that control muscle glycogenolysis via the glycogen phosphorylation enzyme described below see Figure 3.

A simplified overview of glycogen metabolism at rest and during exercise. The sarcolemma separates the muscle cell interior from the interstitial fluid that surrounds the cell. At rest left side , the consumption of carbohydrate stimulates the release of insulin from the pancreas.

Insulin molecules bind to insulin receptors embedded in the sarcolemma. That binding sparks a cascade of intracellular responses that result in the movement of GLUT4 glucose transporters from the interior of the muscle cell into the sarcolemma, allowing for glucose to move into the cell.

Once inside the muscle cell, glucose molecules are readied for inclusion into glycogen. Glycogenin is an enzyme that forms the center of glycogen particles, allowing for the initial formation of glycogen strands. During exercise right side , GLUT4 transporters move into the sarcolemma without the assistance of insulin, aiding in glucose uptake into the cell.

Simultaneously, glycogen degradation increases in response to changes in the concentration of metabolites inside the cell. The glucose molecules from the blood and those released from glycogen are oxidized to produce the adenosine triphosphate ATP molecules required to sustain muscle contraction.

The activity of glycogen synthase is also influenced by the glycogen content of the muscle cell; high glycogen synthase activity is associated with low glycogen levels. After exercise, the restoration of muscle glycogen occurs in a biphasic manner. Periodic carbohydrate supplementation can result in supercompensation of glycogen stores, an advantage after tasks requiring hours of sustained physical effort.

In fact, the second-phase effect can be sustained for several days when carbohydrate intake is maintained. During vigorous exercise, insulin release is blunted, and epinephrine adrenalin is released from the adrenal glands. Epinephrine causes phosphorylation of intramyofibrillar glycogen synthase, ensuring that glycogen synthesis is slowed as glycogen degradation rapidly increases.

As exercise progresses, the activity of glycogen phosphorylase falls as glycogen stores are reduced and as plasma free fatty acids become more available as substrates. Endurance training increases muscle glycogen stores and reduces the reliance on glycogen as a result of the increased use of free fatty acids by active muscle cells, 40 a metabolic adaptation that allows for improved performance. Conversely, the depletion of muscle glycogen causes fatigue.

For example, Krustrup et al. If daily carbohydrate intake is insufficient to fully replace the glycogen metabolized during hard labor or training, muscle glycogen concentration in active muscles will fall progressively over a period of days, a circumstance that is well established in the scientific literature.

As a result, they accidentally benefit from the enhanced metabolic signaling associated with low muscle glycogen. There is even less certainty regarding how muscle glycogen stores influence the adaptations associated with resistance training because there are far fewer studies compared to the number of studies that have focused on the influence of glycogen levels on the adaptations to endurance and interval training.

It may be that the average value for muscle glycogen concentration does not accurately reflect the intramyofibrillar glycogen stores, which appear to have the greatest impact on muscle function. Figure 4 depicts how muscle glycogen levels might vary during 4 days of hard training followed by 2 days of light training.

Muscle glycogen levels can vary widely during training, only reaching supercompensated levels after a few days of rest and light training. In this example, muscle glycogen levels decline during training sessions and are partially restored during subsequent rest and after adequate carbohydrate intake. During hard 2-a-day training sessions day 3 , glycogen concentration can be lowered to the point at which contractile dysfunction fatigue occurs. Illustration based on data from Sherman and Wimer Whenever muscle glycogen stores are reduced as a result of physical activity, consumption of an adequate amount of carbohydrate is required to restore glycogen to normal levels or above supercompensation.

Athletes who train hard most days of the week, at times completing multiple training sessions each day, likely do so with muscle glycogen stores that are rarely fully replenished. For example, Sherman et al.

In their review of the literature, Sherman and Wimer 85 came to the conclusion that high-carbohydrate diets can prevent a fall in muscle glycogen stores over weeks of intense training; in contrast, moderate-carbohydrate diets maintain muscle glycogen stores at levels that are lower but still sufficient to meet the demands of hard training. In an exhaustive review of the literature on dietary carbohydrate intake among athletes, Burke et al. Although training capacity and performance may not be adversely affected by the consumption of moderate-carbohydrate diets, performance is impaired on low-carbohydrate diets.

Burke et al. The high-carbohydrate group improved their performance by 6. In practical terms, athletes should be educated and encouraged to consume enough carbohydrates to replenish at least a sizable portion of their muscle glycogen stores so that training intensity can be maintained from day to day. Fortunately, athletes in training tend to gravitate to high-carbohydrate diets, 1 helping ensure that glycogen stores do not drop so low that training is impaired.

Immediately after physical activity, muscle cells that sustained a substantial decrease in glycogen content are metabolically prepared for rapid glycogenesis. In brief, glycogen use during exercise turns on glycogen synthesis during recovery. When carbohydrates are ingested soon after exercise, insulin release from the pancreas, insulin sensitivity in muscle cells, glucose uptake by muscle cells, and glycogen synthase activity within muscle cells all increase, 94 responses that can remain elevated for 48 hours.

As noted above, timing of carbohydrate intake following physical activity is very important during training and competition requiring multiple efforts during a single day.

Daily carbohydrate intake should reflect the extent of carbohydrate oxidation during training: low on light training days, substantially higher on days of intense or prolonged training. Table 3 contains related practical recommendations.

Recommendations for daily carbohydrate intake for athletes involved in repeated days of strenuous, prolonged physical activity and training. Adapted from Thomas et al. In their review of the literature, Burke et al. It is true that fructose better stimulates liver glycogen restoration and glucose does the same for muscle glycogen, but most physically active people normally ingest enough fructose and glucose in foods and beverages to restore liver glycogen.

Consequently, there is no need to be concerned with the adequacy of dietary fructose intake. It should be noted that combinations of glucose, fructose, and sucrose consumed in sports drinks during exercise have been shown to enhance the rate of fluid absorption from the proximal small intestine and improve the rate of carbohydrate oxidation during exercise, , 2 important factors in sustaining exercise performance.

Solid and liquid forms of carbohydrates are associated with similar rates of glycogen synthesis, — so athletes can meet their daily carbohydrate needs by consuming the carbohydrate-rich foods and beverages they most enjoy. Interestingly, Cramer et al. In the hours soon after exercise, consuming high—glycemic index GI foods can speed muscle glycogen restoration. Low-GI foods are digested and absorbed more slowly than high-GI foods, differences that result in a slower rise in blood glucose and insulin levels, an effect that can last for hours after eating.

The meals were consumed 2 hours prior to exercise. Compared with a placebo treatment no meal , both the low- and high-GI meals improved the total run distance during sprints conducted in the last 15 minutes of the minute session. In contrast with no pre-exercise meal, muscle glycogen levels prior to the final minute segment of exercise were similarly higher with both low- and high-GI meals.

The authors attributed improved run performance to higher muscle and possibly liver glycogen levels prior to the final sprints. Consuming high-GI carbohydrates is effective in increasing muscle glycogen stores after exercise. Increasing the carbohydrate content of the diet to However, Brown et al.

As is often the case in science, additional research is needed to further clarify the conditions in which consuming high-GI foods benefits glycogen restoration and performance. Waxy starches from varietals of potatoes, corn maize , and barley are high in amylopectin and low in amylose; amylopectin is less resistant to digestion because its glucose chains are more highly branched compared with amylose.

For that reason, waxy starches have been studied to assess how their ingestion influences glycogen metabolism and exercise performance. Postexercise muscle glycogen concentrations were similar among treatments, but 24 hours later, less glycogen had been replenished with resistant starch compared with the other treatments.

Total glycogen repletion with glucose was greater than that with waxy starch was greater than that with maltodextrin was greater than that with resistant starch. A companion study by Goodpastor et al. Additional research on the metabolic and performance responses to the ingestion of waxy starches is warranted simply because of the dearth of research in this area.

In terms of overall health, high-quality carbohydrates from unprocessed or minimally processed whole grains, vegetables, beans, dairy foods, and fruits also provide numerous vitamins, minerals, fiber, and many important phytonutrients.

Increased consumption of high-quality carbohydrate foods, such as potatoes and grains, can help ensure adequate consumption of nutrients vital to health, recovery, repair, adaptation, growth, and performance. Aside from the purposeful manipulation of muscle glycogen concentration by diet and training nutrition periodization , periods of extended fasting during Ramadan or in attempts to lose body weight result in metabolic responses that are usually contrary to maintaining high muscle glycogen concentrations, especially if training continues during the fasted state.

Prolonged fasting and very low—carbohydrate diets result in ketosis ketoacidosis , sparing liver and muscle glycogen. As a result, ketotic diets and the ingestion of ketone bodies have been suggested as possible ergogenic aids, particularly for endurance and ultra-endurance athletes.

Related to that conclusion, Vandoorne et al. In short, more research is needed to further clarify the metabolic and performance responses to ketosis—whether induced by fasting, prolonged low-carbohydrate diets, or by the ingestion of ketone bodies—across performance parameters, with special reference to the mental and physical responses during ultra-endurance events when fat oxidation normally predominates. This relatively slow time course makes it impossible for those engaged in multiple bouts of intense exercise during a single day to fully restore muscle glycogen between training sessions or competitive efforts.

However, it is possible to maximize the rate of short-term muscle glycogen repletion so that athletes can replenish more muscle glycogen than might otherwise be possible. Consuming proteins with carbohydrates may be beneficial in stimulating rapid glycogenesis in the hours immediately following exercise, 65 a finding that has implications for speeding recovery between demanding bouts of exercise within the same day. A greater glycogen storage rate may be due to increased muscle glucose uptake and enhanced signaling pathways made possible by the influx of amino acids.

Protein consumption also induces a rise in blood insulin concentration that augments the insulinemic response to carbohydrate ingestion, increasing the rate of glycogen repletion. Consumption of 0. It is clear that adequate consumption of proteins stimulates muscle protein synthesis during rest, although consuming proteins during exercise does not appear to benefit performance or immune function or reduce muscle damage.

Multiday supplementation with creatine monohydrate along with an adequate amount of carbohydrates has been reported to increase muscle glycogen synthesis compared with carbohydrate ingestion alone. Males and females appear to restore muscle glycogen at similar rates following exercise, as long as sufficient carbohydrates and energy are consumed.

The additional protein intake might also help facilitate glycogen synthesis, especially when carbohydrate intake is low. The Dietary Guidelines for Americans identifies gap nutrients as dietary fiber, choline, potassium, magnesium, calcium, and vitamins A, D, E, and C.

Data are from the US Department of Agriculture. Nutrient-rich foods that are high in carbohydrates include grains cereal, rice, pasta, breads, etc , most fruits, some vegetables especially starch vegetables such as potatoes, beans, and peas , and dairy foods.

Fruit and dairy foods contain simple sugars yet are rich in key nutrients. Fruit, especially whole fruit, is a good source of dietary fiber, vitamins, minerals, and water.

Dairy foods, such as milk, are a good source of calcium, vitamin D, and potassium. The nutrition facts panel on packaged food can steer athletes to high-quality carbohydrate foods. The nutrition facts panel contains 2 pieces of information that athletes can readily use to identify carbohydrate content: the serving size and the grams of carbohydrates per serving. The results are also presented in the metabolic profile report. While exercise decreases glycogen content, recovery can create a slight overshoot in glycogen stores.

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Advertisement cookies are used to provide visitors with relevant ads and marketing campaigns. These cookies track visitors across websites and collect information to provide customized ads. Glycogen stored in muscle is primarily used by the muscles themselves, while those stored in the liver are distributed throughout the body—mainly to the brain and spinal cord. Glycogen should not be confused with the hormone glucagon, which is also important in carbohydrate metabolism and blood glucose control.

At any given time, there are about 4 grams of glucose in your blood. When the level begins to decline—either because you have not eaten or are burning glucose during exercise—insulin levels will also drop.

When this happens, an enzyme called glycogen phosphorylase starts breaking glycogen down to supply the body with glucose. For the next eight to 12 hours, glucose derived from liver glycogen becomes the body's primary energy source. Your brain consumes more than half of the body's blood glucose during periods of inactivity.

What you eat and how much you move around also influence glycogen production. The effects are especially acute if you're following a low-carb diet , where the primary source of glucose synthesis—carbohydrate—is suddenly restricted.

When first starting a low-carb diet, your body's glycogen stores can be severely depleted and you may experience symptoms like fatigue and mental dullness. Additionally, any amount of weight loss can have the same effect on glycogen stores. Initially, you may experience a rapid drop in weight. After a period of time, your weight may plateau and possibly even increase.

The phenomenon is partly due to the composition of glycogen, which is primarily water. In fact, the water in these molecules accounts for three to four times the weight of the glucose itself. As such, rapid depletion of glycogen at the onset of the diet triggers the loss of water weight.

Over time, glycogen stores are renewed and the water weight begins to return. When this happens, weight loss may stall or plateau.



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